Enzymes catalyse several reactions that are difficult to perform with chemi
cal catalysts and that are important in the synthesis and modification of d
ifferent polymers in organic solvents. In enzyme-based synthesis, alteratio
n of the reaction medium can have a significant influence on the molecular
weight, polydispersity, yield and architecture of the polymers that are pro
duced. Modification of these macromolecules for industrial applications req
uires an understanding of the different reaction strategies involved.