Genetic optimization of recombinant glycoprotein production by mammalian cells

Authors
Fussenegger, M Bailey, JE Hauser, H Mueller, PP
Citation
M. Fussenegger et al., Genetic optimization of recombinant glycoprotein production by mammalian cells, TRENDS BIOT, 17(1), 1999, pp. 35-42
Citations number
120
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
TRENDS IN BIOTECHNOLOGY
ISSN journal
01677799 → ACNP
Volume
17
Issue
1
Year of publication
1999
Pages
35 - 42
Database
ISI
SICI code
0167-7799(199901)17:1<35:GOORGP>2.0.ZU;2-8
Abstract
Genetically modified mammalian cells are the preferred system for the produ ction of recombinant therapeutic glycoproteins. Other applications include engineering of cell lines for drug screening and cell-based therapies, and the construction of recombinant viruses for gene therapy. This article high lights contemporary core genetic technologies and emerging strategies for g enetically engineering mammalian cells for optimal recombinant-protein expr ession.