Ch. Lochmuller et al., CURRENT STRATEGIES FOR PREDICTION OF RETENTION IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY, Journal of chromatography, 656(1-2), 1993, pp. 3-18
The desire to model chromatographic retention derives from both theore
tical and practical needs. There are fundamental questions concerning
the interactions of molecules in separation systems and the modeling o
f chromatographic retentions is critical for methods development: This
paper reviews the current strategies for predicting retention in HPLC
with emphasis on RP-HPLC. Three main categories are discussed: method
s utilizing a physical model, methods which assume no model, and metho
ds with an abstract or hidden model. The theoretical background, pract
ical application, and relative merits of each approach are discussed.