W. Hoffmuller et al., CATALYTIC FORMATION OF OLIGOPEPTIDES FROM ALPHA-AMINO-ACID ESTERS WITH (P-CYMENE)RUTHENIUM(II) COMPLEXES, EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, (6), 1998, pp. 729-731
Consecutive addition of one-equivalent portions of glycine ethyl ester
to [(p-cymene)Ru(GGGOMe-H+)Cl] leads to considerable amounts of (tetr
a-to nonapeptide)ruthenium complexes in a one-pot reaction, in which t
he (p-cymene)RuCl fragment acts as a catalyst. The analogous reaction
with alanine methyl ester affords AGGG and AAGGG complexes as the main
products. The course of these metal-catalyzed peptide oligomerization
s has been followed by mass spectrometry. The synthesis and characteri
zation of the pentapeptide complex [(C6Me6)Ru(GGGGGOMe-H+)] is reporte
d.