The effects of regular aerobic exercise on blood concentrations on hig
h-density lipoprotein cholesterol and prostacyclin were studied in 18
healthy sedentary boys who exercised on a bicycle ergometer for 1 h, f
our times per week, for 2 months at 75% of their physical working capa
city. The results were compared with those of 10 control boys who did
not participate in any specific program. The exercise group revealed a
significantly higher mean high-density lipoprotein cholesterol and 6-
keto-PGF1a concentration at the end of the training program (p < 0.005
and p < 0.001, respectively). These results suggest that regular aero
bic exercise has beneficial effects upon the high-density lipoprotein
cholesterol and 6-keto-PGF1a in healthy young boys and may be benefici
al in the long term, by preventing atherosclerosis of coronary artery
disease in adulthood.