COMBINATION OF ABO BLOOD-GROUP INCOMPATIBILITY AND GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY - EFFECT ON HEMOLYSIS AND NEONATAL HYPERBILIRUBINEMIA

The incidence (%) of hyperbilirubinemia (serum bilirubin greater than or equal to 257 mu mol/l) was similar in neonates with a combination o f ABO incompatibility and glucose-6-phosphate dehydrogenase (G-6-PD) d eficiency (45%), with ABO incompatibility (54%) or G-6-PD deficiency ( 37%), alone (ns). Carboxyhemoglobin values, corrected for inspired CO, were similarly elevated in all three groups (0.87 +/- 0.32%, 0.82 +/- 0.29%, 0.76 +/- 0.18%, respectively, ns), but correlated with bilirub in only in those with ABO incompatibility alone. ABO-incompatible/G-6- PD-deficient neonates, compared with those with either condition alone , are not at increased risk for hemolysis or hyperbilirubinemia.