ROUTINE VACCINATION AND VACCINE-PREVENTABLE INFECTIONS IN CHILDREN BORN TO HUMAN IMMUNODEFICIENCY VIRUS-INFECTED MOTHERS - EUROPEAN COLLABORATIVE STUDY

Information on vaccinations and vaccine-preventable infections collect ed in a prospective study of children born to human immunodeficiency v irus (HIV)-infected mothers was analysed for reports of adverse reacti ons and to estimate the clinical efficacy of vaccines. No vaccinated, HIV-infected child developed measles (56 child-years' follow-up), mump s (33), rubella (33) or pertussis (239), and only one adverse reaction - to Bacillus Calmette-Guerin (BCG) - was reported. These findings pr ovide limited evidence of the safety and efficacy of routine vaccinati on of HIV-infected children.