PHARMACOKINETICS AND PHARMACODYNAMICS OF MIBEFRADIL IN HYPERTENSIVE PATIENTS WITH VARYING DEGREES OF RENAL-INSUFFICIENCY

Mibefradil, the first member of the tetralol derivatives, a new class of calcium antagonists, is used for the treatment of hypertension and angina pectoris. This study was designed to investigate the effect of varying degrees of chronic renal impairment on mibefradil pharmacokine tics and pharmacodynamics. Neither pharmacokinetic nor pharmacodynamic parameters varied as a function of renal status. Additionally, hemodi alysis removed only a relatively small fraction of drug from the body. It was concluded that the majority of renal-failure patients will not require a change in mibefradil dosage relative to patients with norma l renal function. Following hemodialysis, supplemental mibefradil trea tment should not be necessary.