APPLICABILITY OF LDLR FLANKING MICROSATELLITE POLYMORPHISMS FOR PRENATAL-DIAGNOSIS OF HOMOZYGOUS STATE FOR FAMILIAL HYPERCHOLESTEROLEMIA

Analysis of newly identified microsatellite polymorphisms flanking the low density lipoprotein receptor (LDLR) gene was undertaken in the ki ndred of a child with apparent homozygous LDLR deficiency. The applica bility of these approaches to prenatal diagnosis is considered and com pared with previous approaches applying functional studies of the LDLR in amniotic fibroblasts.