The conventional approach for assessing the environmental impact of wa
stewaters uses a set of global physicochemical and ecotoxicological pa
rameters and is well adapted to the vast majority of wastewaters. When
some chemicals may be particularly harmful for the environment, a spe
cific approach based on a comparison between the predicted environment
al concentration (PEC) and the predicted no-effect concentration (PNEC
) may be used. The four steps of extrapolation required for PNEC evalu
ation are discussed and the importance of the interspecies extrapolati
on is highlighted. It may also be useful to use an integrated approach
relating the characteristics of the wastewater to that of specific co
mpounds. For physicochemical parameters, a simple addition is adequate
, whereas, for ecotoxicity, the problem is more complex. The toxicity
of a mixture of compounds acting by the same mechanism is often descri
bed by the concentration addition model. Although this model is very u
seful for practical applications owing to its simplicity, a statistica
l evaluation of its performance indicates that it slightly overpredict
s the toxicity of mixtures. A new model derived from the statistically
sound ''independence action'' principle and based on a precise mathem
atical description of the dose-response relationship is proposed. Appl
ications of this model to mixtures tested with algae demonstrate the a
ccuracy of this model with the experimental data. (C) 1998 Academic Pr
ess.