Kg. Mountjoy et Jm. Wild, MELANOCORTIN-4 RECEPTOR MESSENGER-RNA EXPRESSION IN THE DEVELOPING AUTONOMIC AND CENTRAL NERVOUS SYSTEMS, Developmental brain research, 107(2), 1998, pp. 309-314
MC4-R mRNA expression was investigated in fetal rats (E14-E20) using i
n situ hybridisation. The autonomic nervous system showed the highest
levels of MC4-R mRNA expression. In the spinal cord, dense signal was
seen over the future intermediolateral cell column and dorsal hem. In
the brain, MC4-R was expressed by E14 in diencephalon neuroepithelia,
telencephalon, lamina terminalis and spinal trigeminal nucleus and was
expressed by E19 throughout many regions of the brain. (C) 1998 Elsev
ier Science B.V.