3D 2D HYDROGEN-BOND NETWORK PREFERENCES FOR 5 NEW RYANOID DERIVATIVES/

Ryanoids are a family of natural compounds that are well known for the ir biological activity in plants as pesticides, and in mammalian muscl e tissue as calcium permeability modulators. As part of an investigati on of the structure-activity relationship of ryanoids, the crystal str uctures of five new compounds were elucidated: 2-deoxy-3-epiryanodol ( C20H32O7), 3-deoxyryanodol hydrate (cinnzeylanol; 2C(20)H(32)O(7).5.15 H(2)O), 2-deoxyryanodol hydrate (2C(20)H(32)O(7).2.5H(2)O), 2,3-dideox yryanodol hydrate (C20H32O6.1.5H(2)O) and 3a,4a,8,8b cahydro-8a,4-(epo xyethano)-benzo[a]pentalen-10-one (C20H28O6) The numerous hydroxyl gro ups on the molecules modulate the crystal packing. Successive modifica tions on ring A induce major changes in the hydrogen-bond scheme, from a three-dimensional (3D) to a two-dimensional (2D) network.