IMMUNOMODULATING ACTIVITIES OF A NATURAL ALPHA(1)-ACID GLYCOPROTEIN AND ITS CARBOHYDRATE CHAINS ATTACHED TO THE PROTEIN-FREE POLYMER

IMMUNOMODULATING effects of a neoglycoconjugate created on the basis o f alpha(1)-acid glycoprotein (AGP) carbohydrate chains and synthetic p rotein-free carrier have been investigated. It was demonstrated that t his pseudo-AGP suppressed PHA-or anti-CDS antibody-induced lymphocyte proliferation in a dose-dependent manner. Pseudo-AGP revealed a simila r antiproliferative effect as the natural AGP samples. Stimulation of the LPS-induced proinflammatory cytokine production by mononuclear cel ls treated with both natural and pseudo-AGP has been also demonstrated . These data show that carbohydrate chains of AGP play a crucial role in the studied biological effect realization.