STRUCTURE AND ACTIVITY STUDIES OF GLYCINE RECEPTOR LIGANDS, PART 3 - STRUCTURE AND CONFORMATION OF L-N-[(5,5-DIPHENYL)-4-OXO-2-IMIDAZOLIDYL]GLYCINATE

As part of our investigation of compounds with potential affinity to t he glycine binding site of MNDA receptors the structure of l-N-[(5,5-d iphenyl)-4-oxo-2-imidazolidyl]glycinate is reported: C19H19N3O3; ortho rombic; P2(1)2(1)2(1); a = 10.273(2), b = 10.309(2), c = 16.721(3) Ang strom; V = 1770.8(6) Angstrom(3); Z = 4; lambda(CuK alpha) = 1.54178 A ngstrom; mu = 0.71 mm(-1); final R = 0.053 for 1002 observed reflectio ns [I > 4 sigma(I)]. Possible tautomers of this structure as well as p ossible conformations of the amino ester chain and their impact on the binding to the glycine binding site of MNDA receptors are discussed. (C) 1998 Elsevier Science B.V. All rights reserved.