INCIDENCE AND CLINICAL MANIFESTATIONS OF ACTIVATED PROTEIN-C RESISTANCE AND FACTOR-V-LEIDEN IN YOUNG-PATIENTS WITH VENOUS THROMBOEMBOLIC DISEASE IN SPAIN

In order to evaluate the actual Incidence and clinical repercussion of activated protein C resistance (APCR) in our area, we performed a coa gulation and thrombophilic study on 65 young patients diagnosed with d eep vein thrombosis and 53 controls. Family and genetic study was carr ied out in APC-resistant patients. We found APCR in 26.15% of patients and the 77.7% of these and their relatives were heterozygous for fact or V Leiden. There's a clear relationship between phenotype APCR and t hrombosis, and also between factor V Leiden and thrombosis.