URINARY-EXCRETION OF TAMM-HORSFALL PROTEIN AND EPIDERMAL GROWTH-FACTOR IN CHRONIC NEPHROPATHY

Citation
O. Torffvit et al., URINARY-EXCRETION OF TAMM-HORSFALL PROTEIN AND EPIDERMAL GROWTH-FACTOR IN CHRONIC NEPHROPATHY, Nephron, 79(2), 1998, pp. 167-172
Citations number
31
Categorie Soggetti
Urology & Nephrology
Journal title
ISSN journal
00282766
Volume
79
Issue
2
Year of publication
1998
Pages
167 - 172
Database
ISI
SICI code
0028-2766(1998)79:2<167:UOTPAE>2.0.ZU;2-W
Abstract
Tamm-Horsfall protein (THP) and epidermal growth factor (EGF) are both synthesized by tubular cells in the distal part of the nephron and ex creted with the urine. The present study examines the urinary excretio n rates of the two peptides in relation to functional tubular markers in patients with chronic nephropathy. Four groups of patients with mod erate to severely reduced renal function were studied: glomerulonephri tis (n = 10), diabetic nephropathy (n = 11), tubulointerstitial nephro pathy (n = 13), and polycystic kidney disease (n = 8). The renal funct ion was evaluated by glomerular filtration rate (GFR) as an indicator for the general renal function, lithium clearance (C-Li) as an indicat or for proximal tubular function, and absolute distal reabsorption of sodium (ADR(NA)) as an indicator for distal tubular function. The excr etion rate of EGF was rather closely correlated with GFR, C-Li and ADR (NA) (Spearman coefficients of variation 0.88, 0.69, and 0.74, respect ively). The correlations between the excretion rate of THP and GFR, C- Li and ADR(NA) were weaker (Spearman coefficients of variation 0.68, 0 .42, and 0.44). When the effect of GFR had been accounted for by multi ple variance analyses, the excretion rates of the two peptides were st ill associated with ADR(NA) but not with C-Li In conclusion, the urina ry excretion rates of especially EGF but also those of THP were correl ated with renal function and distal tubular reabsorption of sodium in patients with chronic nephropathy.