TRANSGENIC MODELS AND SUBCELLULAR PATHOLOGY - DO THEY TELL US WHAT GOES WRONG IN HUNTINGTONS-DISEASE

Authors
REYNOLDS GP DALTON CF
Citation
Gp. Reynolds et Cf. Dalton, TRANSGENIC MODELS AND SUBCELLULAR PATHOLOGY - DO THEY TELL US WHAT GOES WRONG IN HUNTINGTONS-DISEASE, Molecular psychiatry, 3(3), 1998, pp. 192-195
Citations number
25
Categorie Soggetti
Psychiatry,Neurosciences,Biology
Journal title
Molecular psychiatry → ACNP
ISSN journal
13594184
Volume
3
Issue
3
Year of publication
1998
Pages
192 - 195
Database
ISI
SICI code
1359-4184(1998)3:3<192:TMASP->2.0.ZU;2-C
Abstract
Studies of a transgenic mouse model of Huntington's disease have led t o the identification of protein deposits in neuronal nuclei in CAG rep eat expansion diseases. The relationship between neuropathology and th ese nuclear inclusions points to their possible role in pathogenesis.