Several groups of potentially toxic substances and their residues in a
nimals and in animal products require constant monitoring for effectiv
e protection of human health. To properly deal with this challenge, in
1993 four institutes were designated by the European Union as communi
ty reference laboratories (CRLs) for the analysis of residues in food
of animal origin, namely, RIVM in Bilthoven (The Netherlands), CNEVA-L
MV in Fougeres (France), BGVV in Berlin (Germany), and ISS in pome (It
aly). The functions of the four CRLs and the substances they are respo
nsible for have been updated and listed in the annexes to Council Dire
ctive 96/23/EC (April 29, 1996). Particular emphasis is placed on that
part of the activities of the CRLs aimed at promoting and supporting
harmonization of approaches among national reference laboratories (NRL
s). This action is achieved, among others, through coordination of res
earch to develop new analytical methods, implementation of appropriate
quality assurance schemes based on the principles of good laboratory
practice, as well as on EN 45001 criteria, and, last but not least org
anization of interlaboratory exercises to the benefit of the NRLs. The
goal of these proficiency tests is the evaluation of the performance
of each participating laboratory to improve the quality of the analyti
cal data obtained in terms of trueness, credibility, and comparability
. In the light of the mandate prescribed by Council Directive 96/23/EC
the CRL at the ISS is at present responsible for the following catego
ries of residues: (i) all chemical elements; (ii) organochlorine compo
unds including polychlorinated biphenyls; (iii) carbamates and pyrethr
oids; (iv) organophosphorous compounds. Trials of increasing difficult
y are permanently conducted for the determination of organochlorine co
mpounds, on the one hand, and As, Cd, Hg, and Pb, on the other hand. A
detailed description of the two intercomparison exercises already com
pleted for these trace elements and cursory information on the third o
ne still in progress are given. (C) 1998 Academic Press.