The prevention of neural tube defects is a complex problem, The geneti
c associations may ultimately allow the prepregnancy identification of
women at high risk of a neural tube defect. Education of both the pub
lic and healthcare providers has been shown to increase awareness, but
the majority of women do not take folic acid before and in the early
part of pregnancy. Food fortification will be effective in increasing
the folate levels of the population and will have a benefit even at lo
w doses of fortification. (C) 1998 Rapid Science Ltd.