Neurological manifestations of cobalamin deficiency are well known and
various. We describe an uncommon clinical setting where major orthost
atic hypotension was the primary symptom. Recovery was rapidly and com
pletely stabilized with parenteral cobalamin subtitution. There was no
clinical or electrophysiological signs of neuropathic disorder. This
entity is rare but few cases are described in literature. All of them
were reversible with vitamin substitution treatment.