A. Jerschow et N. Muller, CONVECTION COMPENSATION IN GRADIENT-ENHANCED NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY, Journal of magnetic resonance [1997], 132(1), 1998, pp. 13-18
Citations number
26
Categorie Soggetti
Physics, Atomic, Molecular & Chemical","Biochemical Research Methods
Compensation of convection artifacts in gradient-enhanced nuclear magn
etic resonance spectroscopy is introduced. Natural convection caused b
y small temperature gradients over the sample volume can lead to signi
ficant loss of magnetization in gradient-enhanced nuclear magnetic res
onance spectroscopy, sometimes to its complete extinction or partial i
nversion. Even when the effect is small, it still hampers a quantitati
ve interpretation of spectra, e.g., nuclear Overhauser effect buildup
curves. By using modified pulse and gradient sequences it is possible
to avoid the interference of convection, which is demonstrated by way
of two examples: GOESY and GROESY. The principle of convection compens
ation is applicable to a wide variety of gradient-enhanced nuclear mag
netic resonance experiments, in particular those where the interval be
tween a defocusing and a refocusing pulsed field gradient is relativel
y long. (C) 1998 Academic Press.