O. Gauthier et al., MACROPOROUS BIPHASIC CALCIUM-PHOSPHATE CERAMICS - INFLUENCE OF MACROPORE DIAMETER AND MACROPOROSITY PERCENTAGE ON BONE INGROWTH, Biomaterials, 19(1-3), 1998, pp. 133-139
A total of 60 cylindrical 6 x 6 mm samples of a macroporous biphasic c
alcium phosphate (MBCP) ceramic were implanted into a distal femoral s
ite in 30 rabbits. These samples represented six kinds of implants wit
h two different macropore diameters and three different macroporosity
percentages. Analysis of backscattered electron images of implant surf
aces analysed by a factorial design method showed that implants with 5
65 mu m pore size provided more abundant newly formed bone both in per
ipheral and deep pores than those with 300 mu m pore size. No signific
ant differences were found between implants with 40 and 50% macroporos
ity, suggesting that the influence of macropore size on bone ingrowth
was greater than that of macroporosity percentage. MBCP implants with
565 mu m pore diameter and 40% macroporosity represented the optimal a
ssociation for homogeneous and abundant bone ingrowth. (C) 1998 Publis
hed by Elsevier Science Ltd. All rights reserved.