DISTURBED CENTROMERIC MEIOTIC PAIRING LEADS TO CHROMOSOME BREAKS

Authors
CHADOV BF ARTYOMOVA EV BUZYKANOVA GN CHADOVA EV PODOPLELOVA ML
Citation
Bf. Chadov et al., DISTURBED CENTROMERIC MEIOTIC PAIRING LEADS TO CHROMOSOME BREAKS, MUTATION RESEARCH, 323(1-2), 1994, pp. 1-5
Citations number
9
Categorie Soggetti
Genetics & Heredity",Toxicology
Journal title
MUTATION RESEARCH → ACNP
ISSN journal
00275107
Volume
323
Issue
1-2
Year of publication
1994
Pages
1 - 5
Database
ISI
SICI code
0027-5107(1994)323:1-2<1:DCMPLT>2.0.ZU;2-B
Abstract
In Drosophila females an extended deletion of the second autosome peri centric heterochromatin Df(2R)M-S2-10 under heterozygous conditions re sults in the loss of autosome 2, formation of autosomal compounds and stable acrocentric chromosomes (free arms). The presence of an inversi on in the opposite chromosome suppresses the clastogenic effect of the deletion. This effect is presumed to be due to the formation of the c onjugational loop in the region of pericentric heterochromatin which s ubsequently breaks.