SENESCENCE MARKER PROTEIN-30 (SMP30) AND ITS GERONTOLOGICAL SIGNIFICANCE

Authors
FUJITA T SHIRASAWA T MARUYAMA N
Citation
T. Fujita et al., SENESCENCE MARKER PROTEIN-30 (SMP30) AND ITS GERONTOLOGICAL SIGNIFICANCE, Current Science, 74(10), 1998, pp. 872-877
Citations number
20
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Current Science → ACNP
ISSN journal
00113891
Volume
74
Issue
10
Year of publication
1998
Pages
872 - 877
Database
ISI
SICI code
0011-3891(1998)74:10<872:SMP(AI>2.0.ZU;2-1
Abstract
We have isolated and characterized a novel protein designated as senes cence marker protein-30 (SMP30). The amount of SMP30 decreases in an a ndrogen-independent manner with increasing age in the rat liver. SMP30 turned out to be identical to a calcium-binding protein called reguca lcin. In this review; we give an overview of the structure, expression and possible physiological role(s) of SMP30. We also discuss the hypo thetical role of SMP30 in aging and calcium homeostasis.