ADVERSE EVENTS AFTER ORAL VACCINATION AGAINST CHOLERA WITH CVD103-HGR

The goal of the present study was to evaluate the tolerability and acc eptability of an oral cholera vaccine (CVD103HgR) in individuals prepa ring for travel to countries endemic for cholera. 2545 Austrian travel ers between 6 months and 81.5 years of age received a single dose of C VD103HgR and were asked to complete a questionnaire for documentation of adverse events during a 7 day period post immunisation. Events were recorded regardless of whether they were caused by concomitant vaccin ations or other factors and thus, a causative relationship was not nec essarily present. Despite this drawback and the possibility of overrep orting, this study has proven a low frequency in side effects and the good tolerability of CVD103HgR. Occasional gastrointestinal side effec ts (15% diarrhea, 8.1% nausea, 1.1% vomiting) were seen and were of mi ld character and probably a consequence of associated intake of sodium bicarbonate buffer. Other events (7% skin eruptions, 2.7% fever) were mild and considered as harmless (or not vaccine related). The results show that the oral cholera vaccine CVD103HgR was well tolerated and a ccepted by travelers.