INTRAUTERINE INSEMINATIONS WITH HUSBANDS SPERM - CONCLUSIONS OF A 5-YEARS EXPERIENCE

We analyzed retrospectively 936 intrauterine insemination (IUI) cycles with husband's sperm (384 couples). Superovulation and induction moni toring occured in the majority of cases; IUI was timed 36-40 h after o vulatory hCG. The overall pregnancy rate per cycle (PR/C) was 11,4 % ( 107/936). Data analysis demonstrated that PR/C decreased with infertil ity duration, woman's age (especially after 38 years old) and number o f attempts (significantly after the 4 th cycle). Superovulation tin pa rticular by antiestrogens) and induction monitoring seemed to provide an increase in cycle pregnancy rate. Highest PR/C were observed in dys ovulation and male infertility groupes. in cases of sperm defects, our data showed that 2 parameters had a significant influence on pregnanc y outcome, the number of motile progressive inseminated spermatozoa (> 300000) and the spermatozoa survival rate after 24 h (>50%). As a conc lusion, intrauterine insemination can be proposed as a satisfying trea tment of infertility, if precise protocol is followed and its indicati ons well-defined.