PARADOXIC DECREASES IN ATHEROSCLEROTIC PLAQUE MASS IN INSULIN-TREATEDPATIENTS

This study assessed the impact of diabetes mellitus on atherosclerotic lesion formation. Seventy insulin-treated diabetics, 150 nan-insulin- treated diabetics, and 607 nondiabetics with chronic anginal syndomes and de nova native coronary stenoses were studied using (1) angiograph y, and (2) intravascular ultrasound (reference and lesion arterial, lu men, and plaque areas; area stenosis [reference-lesion/reference lumen area]; remodeling index [reference-lesion lumen area/lesion-reference plaque area]; and slope of the regression line relating lumen area to plaque burden [plaque/arterial area]). Despite being diabetic for lon ger and having similar lumen compromise, insulin-treated patients had (1) less reference plaque (8.3 +/- 3.4 vs 10.5 +/- 4.5 mm(2) p = 0.001 5), (2) less stenosis plaque (13.0 +/- 4.9 vs 16.9 mm(2), p <0.0001), (3) smaller reference arterial areas (17.1 +/- 5.4 vs 19.7 +/- 6.2 mm( 2), p = 0.0063), and (4) smaller stenosis arterial areas (15.3 +/- 4.9 vs 19.5 +/- 6.5 mm(2), p <0.0001) than non-insulin-treated diabetics. With use of multivariate linear regression analysis, insulin use was an independent land negative) predictor of reference plaque and arteri al areas (p = 0.0308 and p = 0.0179) and stenosis plaque and arterial areas (p = 0.0117 and p = 0.0066). This was also true when normalized for body surface area. The remodeling index showed that insulin treatm ent resulted in an exaggerated impact of plaque accumulation on lumen compromise. This was confirmed by the slope of the regression line rel ating lumen area to plaque burden. Patients with a longer duration of diabetes who were treated with insulin for greater than or equal to 1 year had (paradoxically) less reference segment and stenosis plaque ac cumulation. Possible explanations include impaired adaptive remodeling and/or arterial land plaque) shrinkage. (C) 1998 by Excerpta Medica, Inc.