ENHANCING THE SURVIVAL OF ASPIRATED HUMAN FAT INJECTED INTO NUDE-MICE

Injection of aspirated fat is now the most commonly used technique for the filling of depressed areas. Partial absorption of the injected fa t is the main limitation of this procedure. Cariel T.M. is an enriched serum-free cell culture medium, its ability to enhance the survival o f human aspirated fat grafts was investigated in the nude mouse model. A volume of 0.75-cc Cariel preprocessed fat was injected under the sc alp skin of 16 nude mice in the experimental group, and the same volum e of saline preprocessed fat was injected to 15 control group of mice. Significant maintenance of the weight, 46 percent in the experimental group compared with 29 percent in the control group (p < 0.008), and the volume, 44 percent in the experimental group compared with 31 perc ent in the control group (p < 0.026), was observed, after 15 weeks, in this newly used model. It seems that addition of the nutrients enrich ed with anabolic hormones enabled the survival and take of more adipos e cells in the graft.