CHEMICAL SYNTHESIS OF GDP-L-GALACTOSE AND ANALOGS

Succinct syntheses for L-galactose, 3-deoxy-L-xylo-hexose (3-deoxy-L-g alactose), 6-deoxy-L-galactopyranose (L-fucose) and 3,6-dideoxy-L-xylo -hexose (3,6-dideoxy-L-galactose) have been developed starting from co mmercially available L-galactono-1,4-lactone. L-Galactose and variants were then converted to the guanosine diphosphate derivatives, via the formation of the anomeric phosphates and coupling to guanosine monoph osphate morpholidate. (C) 1998 Elsevier Science Ltd. All rights reserv ed.