Wh. Finlay et al., VARIATIONS IN PREDICTED REGIONAL LUNG DEPOSITION OF SALBUTAMOL SULFATE BETWEEN 19 NEBULIZER TYPES, Journal of aerosol medicine, 11(2), 1998, pp. 65-80
Citations number
36
Categorie Soggetti
Public, Environmental & Occupation Heath","Respiratory System
Regional lung dosages are estimated for 19 different nebulizer types,
and variations in these dosages within each nebulizer type are given.
Experimental methods are used to characterize the aerosols inhaled in
vitro (inhalation flow rate = 300 mL/s, tidal volume = 750 mL) from ne
bulizers filled with 2.5 mL of Ventolin (1 mg/mL of salbutamol sulphat
e in normal saline) under ambient conditions of 50% +/- 3% relative hu
midity (RH), 22 degrees C +/- 1 degrees C. These data are input into a
hygroscopic, mathematical lung deposition model to estimate regional
lung dosages for a scaled Weibel A lung. The deposition model is a two
-way coupled model (i.e., it includes the effects of droplet heat and
mass transfer on the surrounding environment and vice versa). As a per
centage of normal dose placed in the nebulizer, regional dosages diffe
red significantly between the different nebulizer types (P < 0.01) and
varied from 3.1% to 23.4%, 1.6% to 10.6%, 1.6% to 12.8%, and 1.8% to
9.5% for lung, tracheobronchial, alveolar, and extrathoracic depositio
n, respectively. Variations in regional dosages between nebulizers of
each type had standard deviations that mere, on average, less than 2%
of the nominal dose. Of the three nebulizer classes tested (ultrasonic
, conventional, and vented), no class consistently gave higher regiona
l dosages than the other two classes. Good agreement with published in
vivo scintigraphic data mas found (P > 0.01) in lung dosages.