EFFECTS OF RECOMBINANT HUMAN SERUM-ALBUMIN ON ASCITES IN RATS WITH PUROMYCIN AMINONUCLEOSIDE-INDUCED NEPHROPATHY

1. Recombinant human serum albumin (rHSA) (1 g/kg) significantly decre ased the weight of ascites in rats with puromycin aminonucleoside-indu ced nephropathy.2. Furosemide (1-30 mg/kg) did not significantly reduc e the weight of ascites in this model. 3. A combination of rHSA (1 g/k g) with furosemide (5 mg/kg) significantly decreased the weight of asc ites in this model compared with furosemide alone. 4. In consideration of these results, rHSA can be a substitute for human serum albumin pr oducts prepared from human plasma in therapy for ascites or edema in f urosemide-resistant nephrotic syndrome. (C) 1998 Elsevier Science Inc.