SYNTHESIS, ANTIVIRAL AND CYTOSTATIC ACTIVITIES OF CARBOCYCLIC NUCLEOSIDES INCORPORATING A MODIFIED CYCLOPENTANE RING - PART 2 - ADENOSINE AND URIDINE ANALOGS

Six new carbocyclic nucleosides were prepared by mounting a purine (co mpounds 5-7), 8-azapurine (compounds 9 and 10) or pyrimidine (compound 13) base on the amino group of 3-(aminomethyl)-1,2,2-trimethylcyclope ntylmethanol (2). The antiviral activity of compounds 5-7, 10 and 13, and their cytostatic activity, were evaluated. At subtoxic concentrati ons, the compounds showed no or marginal antiviral activity. Compound 5 showed moderate inhibition on tumor cell proliferation.