BILATERAL ANTERIOR ISCHEMIC OPTIC NEUROPATHY FOLLOWING INFLUENZA VACCINATION

Optic neuritis is an occasional complication of vaccination. Visual lo ss can be unilateral or bilateral, and most patients recover substanti ally without treatment. The presumptive mechanism is an immune-mediate d demyelinating injury of the optic nerve. We report two patients who had permanent visual loss following influenza vaccination. Their patte rn of visual loss, segmental optic disc changes, and failure of visual recovery were atypical for demyelinating optic neuritis and reminisce nt of a primary ischemic injury to the optic nerve. We speculate that an immune complex-mediated vasculopathy following vaccination can caus e anterior ischemic optic neuropathy. Clinicians should be aware of th is entity because of the less favorable prognosis for visual recovery in these cases.