HIGH-RISK GESTATIONAL TROPHOBLASTIC DISEASE - ANALYSIS OF CLINICAL PROGNOSES

Purpose of investigation: An attempt to better define factors leading to patient survival in the high-risk group of malignant, gestational t rophoblastic disease (GTD). Methods: From January 1, 1997 to December 31, 1995 25 cases of malignant high-risk GTD were retrospectively coll ected to evaluate prognostic factors by univariate and multivariate an alysis. Results: We identified the presence of liver metastases and/or brain metastases and the presence of intestinal metastases as signifi cant by using univariate analysis. However, only the presence of liver metastases of brain metastases was significant by multivariate analys is (p=0.009). Conclusions: Although a high-risk group of GTD can be id entified according to the modified World Health Organization (WHO) pro gnostic scoring system, liver metastases were not emphasized (only two points) in this scoring system. We suggested that these risk factors, including brain metastases and liver metastases, should be weighted m ore than other risk factors.