HYDROLYSIS OF NUCLEOSIDE PHOSPHATES - PART 12 - FACILITATION OF THE COPPER(II)-PROMOTED DEPHOSPHORYLATION OF ADENOSINE 5'-TRIPHOSPHATE (ATP(4-)) BY THE ANTIVIRAL NUCLEOTIDE ANALOG, 9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE (PMEA)

Authors
SIGEL H BLINDAUER CA HOLY A DVORAKOVA H
Citation
H. Sigel et al., HYDROLYSIS OF NUCLEOSIDE PHOSPHATES - PART 12 - FACILITATION OF THE COPPER(II)-PROMOTED DEPHOSPHORYLATION OF ADENOSINE 5'-TRIPHOSPHATE (ATP(4-)) BY THE ANTIVIRAL NUCLEOTIDE ANALOG, 9-[2-(PHOSPHONOMETHOXY)ETHYL]ADENINE (PMEA), Chemical communications, (11), 1998, pp. 1219-1220
Citations number
23
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
11
Year of publication
1998
Pages
1219 - 1220
Database
ISI
SICI code
1359-7345(1998):11<1219:HONP-P>2.0.ZU;2-7
Abstract
The antiviral PMEA is able to mimic the structuring adenosine 5/-monop hosphate (AMP(2-)) in the reactive intermediate, [Cu-3(ATP)(AMP)(OH)]( -), and to promote the dephosphorylation of ATP; PMEA is about twice a s effective as (the ultimate product of this hydrolysis) AMP.