ACIDIC FIBROBLAST GROWTH-FACTOR RESCUES GERBIL HIPPOCAMPAL-NEURONS FROM ISCHEMIC APOPTOTIC DEATH

Authors
CUEVAS P CARCELLER F REIMERS D DETEJADA IS GIMENEZGALLEGO G
Citation
P. Cuevas et al., ACIDIC FIBROBLAST GROWTH-FACTOR RESCUES GERBIL HIPPOCAMPAL-NEURONS FROM ISCHEMIC APOPTOTIC DEATH, Neurological research, 20(3), 1998, pp. 271-274
Citations number
27
Categorie Soggetti
Neurosciences,"Clinical Neurology
Journal title
Neurological research → ACNP
ISSN journal
01616412
Volume
20
Issue
3
Year of publication
1998
Pages
271 - 274
Database
ISI
SICI code
0161-6412(1998)20:3<271:AFGRGH>2.0.ZU;2-9
Abstract
Neurotrophic factors have been shown to support the survival of injure d neurons and promote their recovery. Here, we investigated whether ac idic fibroblast growth factor (aFGF) could modify programmed cell deat h caused by transient forebrain ischemia in the gerbil. The data show that systemic administration of 2.6 mu g aFGF after 5 min ischemia fol lowed by 7 days of brain reperfusion significantly (p < 0.05) reduced the occurrence of apoptotic cell death in CA1 neurons. These data sugg est that aFGF would contribute to brain protection after acute stroke.