CORRELATION OF M235T DNA POLYMORPHISM WITH CARDIOVASCULAR AND ENDOCRINE RESPONSES DURING PHYSICAL EXERCISE IN HEALTHY-SUBJECTS

In our experiments, we evaluated the possible effect of M235T molecula r variant of the angiotensinogen gene on the response to a physical wo rkload. A group of volunteers was composed of healthy male subjects, a pproximately of the same weight and height, same age and not actively trained. None of these subjects was under any medication. Blood sampli ng was carried out via an indwelling catheter. Besides blood pressure and heart rate, angiotensin I, angiotensin II, epinephrine and norepin ephrine concentrations were measured in the blood. Our results suggest that only the response of diastolic blood pressure during submaximal exercise corresponded to the presence of M235T molecular variant. In a ll other parameters we found no significant correlation of the respons e with the M235T molecular variant.