INFLUENCE OF PROTEIN-MALNUTRITION ON TERATOGENICITY OF ACETYLSALICYLIC-ACID IN RATS

Authors
HAMED MR ALASSY YS EZZELDIN E
Citation
Mr. Hamed et al., INFLUENCE OF PROTEIN-MALNUTRITION ON TERATOGENICITY OF ACETYLSALICYLIC-ACID IN RATS, Human & experimental toxicology, 13(2), 1994, pp. 83-88
Citations number
20
Categorie Soggetti
Toxicology
Journal title
Human & experimental toxicology → ACNP
ISSN journal
09603271
Volume
13
Issue
2
Year of publication
1994
Pages
83 - 88
Database
ISI
SICI code
0960-3271(1994)13:2<83:IOPOTO>2.0.ZU;2-D
Abstract
The effect of protein malnutrition (PM) on the embryotoxicity and tera togenicity of aspirin in rats has been studied. Protein malnourishment was produced from Days 7 to 21 of gestation by limiting the casein co ntent of the diet to 5% in comparison to 20% for the normal animals, S ix dose levels of aspirin (50-175 mg kg(-1)) were administered p.o. fr om Days 8 to 11 of pregnancy. Aspirin from 75 mg kg(-1) d(-1) induced growth retardation, embryolethality and teratogenicity, as shown by ex ternal, skeletal and visceral malformations. All these effects were po tentiated by protein malnutrition.