VITAMIN-C IN CC14 HEPATOTOXICITY - A PRELIMINARY-REPORT

Authors
ADEMUYIWA O ADESANYA O AJUWON OR
Citation
O. Ademuyiwa et al., VITAMIN-C IN CC14 HEPATOTOXICITY - A PRELIMINARY-REPORT, Human & experimental toxicology, 13(2), 1994, pp. 107-109
Citations number
17
Categorie Soggetti
Toxicology
Journal title
Human & experimental toxicology → ACNP
ISSN journal
09603271
Volume
13
Issue
2
Year of publication
1994
Pages
107 - 109
Database
ISI
SICI code
0960-3271(1994)13:2<107:VICH-A>2.0.ZU;2-G
Abstract
1 The hepatotoxic effect of CC14 was studied in the rat by using 3 wel l established liver function tests (plasma glucose, bilirubin and prot eins) as indices of hepatic integrity. 2 The protective effect of vita min C against this hepatotoxicity was also investigated. 3 CC14 (8 ml kg(-1) body weight) caused a decrease in the levels of plasma conjugat ed bilirubin, glucose and protein. 4 Vitamin C (2 g kg(-1) body weight ) prevented liver damage induced by CC14. The possible mechanisms of p rotection are highlighted.