THE SYNTHESIS OF A CHIRAL FLUOXETINE INTERMEDIATE BY CATALYTIC ENANTIOSELECTIVE HYDROGENATION OF BENZOYLACETAMIDE

Citation
Hl. Huang et al., THE SYNTHESIS OF A CHIRAL FLUOXETINE INTERMEDIATE BY CATALYTIC ENANTIOSELECTIVE HYDROGENATION OF BENZOYLACETAMIDE, Tetrahedron : asymmetry, 9(10), 1998, pp. 1637-1640
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
ISSN journal
09574166
Volume
9
Issue
10
Year of publication
1998
Pages
1637 - 1640
Database
ISI
SICI code
0957-4166(1998)9:10<1637:TSOACF>2.0.ZU;2-U
Abstract
In the presence of a chiral BINAP-ruthenium(II) catalyst, asymmetric h ydrogenation of beta-keto propanoic acid N-methyl amide under 200 psi of hydrogen pressure furnished the corresponding 3-hydroxypropanoic ac id N-methyl amide as the single enantiomer. The product can be used as an intermediate for chiral fluoxetine. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.