Hl. Huang et al., THE SYNTHESIS OF A CHIRAL FLUOXETINE INTERMEDIATE BY CATALYTIC ENANTIOSELECTIVE HYDROGENATION OF BENZOYLACETAMIDE, Tetrahedron : asymmetry, 9(10), 1998, pp. 1637-1640
In the presence of a chiral BINAP-ruthenium(II) catalyst, asymmetric h
ydrogenation of beta-keto propanoic acid N-methyl amide under 200 psi
of hydrogen pressure furnished the corresponding 3-hydroxypropanoic ac
id N-methyl amide as the single enantiomer. The product can be used as
an intermediate for chiral fluoxetine. (C) 1998 Published by Elsevier
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