CHEMOENZYMATIC SYNTHESIS OF THE 2 ENANTIOMERS OF 7-AZATRYPTOPHAN

Authors
LECOINTE L ROLLANDFULCRAND V ROUMESTANT ML VIALLEFONT P MARTINEZ J
Citation
L. Lecointe et al., CHEMOENZYMATIC SYNTHESIS OF THE 2 ENANTIOMERS OF 7-AZATRYPTOPHAN, Tetrahedron : asymmetry, 9(10), 1998, pp. 1753-1758
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
10
Year of publication
1998
Pages
1753 - 1758
Database
ISI
SICI code
0957-4166(1998)9:10<1753:CSOT2E>2.0.ZU;2-0
Abstract
7-Azatryptophan is an unnatural alpha-amino acid with a very potent fl uorescent activity. It is used as a vehicle for probing the structure and dynamics of proteins and peptides. Diastereoselective alkylation, diastereoselective protonation and enzymatic resolution have been test ed for preparing enantiomerically pure 7-azatryptophan. (C) 1998 Elsev ier Science Ltd. All rights reserved.