EFFECT OF CHRONIC ADMINISTRATION OF TAMOXIFEN ON FERTILITY IN MALE BONNET MONKEYS (MACACA-RADIATA)

Authors
RAO AJ RAMACHANDRA SG RAMESH V KRISHNAMURTHY HN JAYARAMAN S GOPALAKRISHNAN K JUNEJA HS
Citation
Aj. Rao et al., EFFECT OF CHRONIC ADMINISTRATION OF TAMOXIFEN ON FERTILITY IN MALE BONNET MONKEYS (MACACA-RADIATA), Andrologia, 30(3), 1998, pp. 129-132
Citations number
15
Categorie Soggetti
Andrology
Journal title
Andrologia → ACNP
ISSN journal
03034569
Volume
30
Issue
3
Year of publication
1998
Pages
129 - 132
Database
ISI
SICI code
0303-4569(1998)30:3<129:EOCAOT>2.0.ZU;2-8
Abstract
Administration of Tamoxifen via the Alzet pump at a rate of 50 mu g hr (-1) for 90 days in the adult male bonnet monkeys Macaca radiata had n o effect on the serum testosterone concentration determined at 10 AM a nd 10 PM as well as total sperm count determined at 15-day intervals o ver a period of 260 days. However, a significant reduction in sperm mo tility was observed beyond 90 days up until the 225th day. Breeding st udies conducted from day 90 to 260 revealed that these males were infe rtile.