EVALUATION OF SEMINAL PLASMA PARAMETERS IN PATIENTS WITH CHRONIC PROSTATITIS OR LEUKOCYTOSPERMIA

Though detailed cytological and microbiological diagnostic procedures are routinely carried out in male genital tract infection, the correct diagnosis and localization of inflammation or infection is often diff icult. In this prospective study, the relevance of the seminar plasma markers PMN elastase, complement C3, CRP, fructose, PSP 94, PSA, and a lpha-glucosidase was investigated in 13 patients with chronic prostati tis, 31 patients with significant leukocytospermia, and 58 patients wi th non-inflammatory diseases (controls). Statistically relevant result s were obtained for PMN elastase when comparing chronic prostatitis wi th controls, leukocytospermia with controls (P<0.001) and chronic pros tatitis with leukocytospermia vs. controls (P<0.05) and for fructose/e jaculate leukocytospermia vs. controls (P<0.05). No statistically rele vant differences were found for C-reactive protein, alpha-glucosidase, PSA and prostatic secretory protein (PSP 94). To delimit genital trac t inflammation from non-inflammatory patients, cutpoint levels for PMN elastase of 230 ng ml(-1) and for C3c of 0.01 g l(-1) were suggested. PMN elastase was shown to possess the strongest discriminating power. The assessment of a cutpoint for fructose to indicate seminal vesicle dysfunction is not possible as the significance level is weak (P<0.05 ).