COMPARATIVE GENE ASSIGNMENT IN ATELES PANISCUS CHAMEK (PLATYRRHINI, PRIMATES) AND MAN - ASSOCIATION OF 3 SEPARATE HUMAN SYNTENIC GROUPS ANDEVOLUTIONARY CONSIDERATIONS
F. Canavez et al., COMPARATIVE GENE ASSIGNMENT IN ATELES PANISCUS CHAMEK (PLATYRRHINI, PRIMATES) AND MAN - ASSOCIATION OF 3 SEPARATE HUMAN SYNTENIC GROUPS ANDEVOLUTIONARY CONSIDERATIONS, Chromosoma, 107(2), 1998, pp. 73-79
Regional assignment of eight markers to chromosome 2 of Ateles paniscu
s chamek (APC) confirmed a syntenic association similar to human (HSA)
12q + 14q + 15q. Three HSA 12q markers (RAP1B, PAH and ALDH2) were al
located to a shortest region of overlap (SRO) in APC 2p and found to b
e syntenic to other HSA 12q markers (PEPB and TCF1). Five HSA 14q mark
ers (CTLA, PAX9, NSP, FOS and CHGA) were allocated to APC 2q and found
to be syntenic to other HSA 14q markers (NP, TGM1, and CALM1) and to
four HSA 15q markers (THBS1, B2M, HEXA and MPI) but dissociated from m
arkers close to HSA 14qter (CKB) and HSA 15qter (FES-IDH2). Karyotypic
comparisons showed an evident homoeology between APC 2p and HSA 12q w
hile APC 2q was similar to an HSA 14qter::HSA 15qter fusion product. C
omparative gene mapping data show that the HSA 14q + HSA 15q syntenic
association is an ancestral mammalian gene cluster that has been maint
ained in several primate taxa. Conversely, in Ateles, it has been furt
her associated with HSA 12q while, in Hominoids and Cebus, it has been
independently dissociated into two separate syntenic groups, similar
to HSA 14q and HSA 15q.