BLOOD-COAGULATION FACTORS CHANGES DURING LIVER-REGENERATION IN RATS

Effects of partial hepatectomy on blood coagulation factors were inves tigated in rats. Analysis were performed 24, 48 and 72 hours after sur gery. Howell's time was significantly higher after 24 and 48 h compare d to the control value. Prothrombin time was significantly prolonged a fter 24 h. Partial thromboplastin time did not differ significantly in any time. FII values were significantly reduced after 24 and 48 h, bu t FV values only after 24 h. FVII showed significant decrease after 24 h, but significant increase at 48 h. FVIII and ATIII average values w ere significantly lower after 24, 48 and 72 h. Plasma fibrinogen incre ased. Significant differences were observed 48 and 72 h after surgery. Differences in normalization time of these coagulation factors are mo st probably the consequence of their synthesis in various cell types, regenerated at different periods after partial hepatectomy.