TRANSIENT FOCAL NEUROLOGIC DEFICITS ASSOCIATED WITH HYPOGLYCEMIA IN CHILDREN WITH INSULIN-DEPENDENT DIABETES-MELLITUS

We describe 54 transient focal neurologic deficits (TFND) episodes in 44 children under 18 y observed retrospectively during a 5-y period (1 991-96). Mean age and duration of insulin-dependent diabetes mellitus (IDDM) were 8.4 and 3.4 y, respectively. None of the children had a hi story of seizure disorder and only one had a personal history of migra ine. Twenty-nine episodes were characterized by right- and 25 by left- sided hemiparesis. Three of six patients who presented mon than one ev ent had alternate episodes of right- and left-sided hemiparesis. On 8 occasions the episode was preceded by a brief convulsion, in 39 it was not witnessed, and in 7 it was certainly absent. Hypoglycaemia (less than or equal to 2.77 mmol/l) was documented on 26 occasions. On 18 of these 26 occasions, the episodes did not resolve promptly after sugar administration The clinical course was benign, all patients remained neurologically normal and none developed migraine at follow up. Episod es of TFND were associated with hypoglycaemia in the majority of our c ases and we do not consider invasive investigations to be mandatory, s ince the long-term prognosis was invariably good.