PREVENTION OF HYPOGLYCEMIA IN A PATIENT WITH TYPE IB GLYCOGEN-STORAGE-DISEASE BY AN AMYLASE (ALPHA-GLUCOSIDASE) INHIBITOR

Patients with type Ib glycogen storage disease (GSD Ib) are susceptibl e to hypoglycaemic episodes. To determine whether an amylase (alpha-gl ucosidase) inhibitor, voglibose, can be useful in the control of hypog lycaemia, we tried it in a 14-y-old male with GSD Ib. Oral administrat ion of voglibose prolonged the duration of normoglycaemia and reduced the incidence of hypoglycaemia attacks. These findings indicate that v oglibose may be useful for preventing hypoglycaemia in GSD Ib patients .