A NEW CASE OF TRANSLOCATION T(6-11)(Q21-Q23) IN A THERAPY-RELATED ACUTE MYELOID-LEUKEMIA RESULTING IN AN MLL-AF6Q21 FUSION

A new case of translocation t(6;11)(q21;q23) in a patient with therapy -related acute myeloblastic leukemia is reported. The translocation re sults in fusion of the MLL and AF6q21 genes. The breakpoint with AF6q2 1 is located within the sequences encoding the AF6q21 fork head motif. The similar location of the localization of the chromosome 6 breakpoi nts in the present case and in the first case reported suggests their nonrandom localization. In addition, treatment for Hodgkin's disease p rior to leukemia in both t(6;11)(q21;q23) cases suggests an associatio n of this translocation with therapy-related leukemias, as reported fo r the recently described t(11;16)(q23;p13.3). (C) 1998 Wiley-Liss, Inc .