A NEW DOSAGE REGIMEN FOR TOPICAL APPLICATION OF CIPROFLOXACIN IN THE MANAGEMENT OF CHRONIC SUPPURATIVE OTITIS-MEDIA

The clinical and bacteriologic efficacy of topically applied ciproflox acin was studied in 60 patients with chronic suppurative otitis media, Two hundred fifty and 125 mu g/ml concentrations of ciprofloxacin sol utions were given to two groups of patients. The duration of therapy w as determined according to the clinical cure at follow-up. More than 2 1 days of therapy was not needed in any patient, The clinical cure rat e with 250 mu g/ml ciprofloxacin was 78.1% at 14 days and with 125 mu g/ml it was 83.3%, However, a 100% clinical cure rate and complete bac teriologic eradication was obtained in 21 days in both groups, In each group only one patient had otomycosis by the fourteenth day of therap y, although ear discharge had ceased, It was concluded that 125 mu g/m l ciprofloxacin could be applied as successfully as 250 mu g/ml, and t he duration of therapy had to be at least 14 days. This new dosage reg imen can be adopted as an optimal dosage for ototopical application of ciprofloxacin in chronic suppurative otitis media. it will also obvio usly decrease the expense of therapy.