LOCAL VS. SYSTEMIC IMMUNE AND HEMOSTATIC RESPONSE TO HIP-ARTHROPLASTY

Local and systemic immune and haemostatic responses were studied in 10 patients, aged 57-78 years, undergoing elective hip arthroplasty. Cyt okines, soluble cytokine receptors, interleukin-1 receptor antagonist, soluble adhesion molecules, antithrombin, fibrin, soluble and fibrin D-dimer were analysed in wound drainage blood and in blood taken from the systemic circulation for up to 24 h post-operatively. Wound draina ge blood concentrations of cytokines, interleukin-1 receptor antagonis t and soluble cytokine receptors were increased compared with those in the systemic circulation except for the soluble interleukin-6 recepto r. In wound drainage blood, soluble tumour necrosis factor receptors ( P<0.05), interleukin-1 receptor antagonist (P<0.05) and interleukin-6 (P<0.05-<0.01) increased during the study period. In blood from the sy stemic circulation interleukin-6 increased (P<0.05) while the soluble interleukin-6 receptor decreased (P<0.05) compared with pre-operative values. Concentrations of soluble adhesion molecules did not change. W ound drainage blood showed marked hypercoagulation. After hip arthropl asty pro-inflammatory cytokines and their inhibitors were mainly confi ned to the local trauma site. A predominance for inhibitors was noted.